Monocytic and lymphocytic inflammatory reaction during myocardial infarction complicated with acute heart failure in patients with type 2 diabetes mellitus

Background . The processes of inflammation and repair in the area myocardial infarction (MI) are carried out regulated by various populations immune cells, including monocytes, lymphocytes, NK-cells. success recovery after risk developing acute heart failure (AHF) depend on their adequate interaction. presence type 2 diabetes mellitus (T2DM), which chronic low-gradient occurs, can affect monocytic lymphocytic response MI, may contribute to development AHF. Objective assess features responses patients with MI T2DM complicated Design methods study included 121 (38 them AHF). control group 59 without (including 13 For all within 1 day, days 3, 5 12 total number monocytes monocytes-to-lymphocytes ratio (MLR), subpopulations T-lymphocytes NK cells (T&NK-cells) were determined flow cytometry. Results In T2DM, different did not differ depending AHF, compared day CD14(+)CD16(-)monocytes was higher: 1018 (824; 1144) vs 593 (557; 677) cells/?L, p <0,01, 3 5, CD16(+) T&NK-cells lower: 122 (95; 275) cells/?L 307 (220; 406) respectively (p = 0,03); (117 (61; 228) 437 (408; 545) respectively, < 0,01. On 12th AHF lymphocytes CD16(+)T&NK-cells counts lower comparison AHF: 1856 (1245; 1975) 2294 (1827; 2625) 0,04; 268 (128; 315) 344 (226 ; 499) cells/ ?L, 0,04. Conclusion is associated a low absence pronounced response. non-diabetic patients, an increase CD16(-)monocytes CD16 (+) T&N?-cells.